Effects of lawsone and lawsone methyl ether on cyclooxygenase activity, redox balance, and organ-specific toxicity: An integrated computational and experimental study. (PubMed, Toxicol Rep) - Oct 7, 2026 - "Molecular docking analysis revealed favorable binding scores/interactions of LME against COX-1 (-5.9 kcal/mol), lipoxygenase (LOX; -6.6 kcal/mol), NAD(P)H oxidase (-5.6 kcal/mol), and myeloperoxidase (MPO; -4.7 kcal/mol), surpassing lawsone and reference inhibitors (aspirin, and zileuton). However, in a 28-day repeated oral toxicity study, a no-observed-adverse-effect level (NOAEL) of at least 50 mg/kg was established for both the compounds, with no toxicity observed across various rat parameters. Overall, LME was better tolerated than lawsone, exhibiting COX inhibitory and redox-modulatory effects, but its therapeutic significance requires further validation."
Journal • Inflammation • CAT • MPO
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Asad Ur Rahman; Muhammad Ajmal Shah; Muhammad Khan; Nadeem Ahmad; Pharkphoom Panichayupakaranant; Phisit Khemawoot; Tehmina Sohail; Zaheer Ul-Haq
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