Familial Hypercholesterolemia. (PubMed, Methodist Debakey Cardiovasc J) - Sep 20, 2026 - "Prompt recognition and treatment with statins, often combined with ezetimibe, modifies the natural course of the disease...In statin-intolerant patients, bempedoic acid may provide additional therapeutic options. The most severe form, homozygous FH (HoFH), has an estimated prevalence of ~1 in 367,000 individuals and is associated with ASCVD in youth, calcific aortic stenosis, and a markedly reduced life expectancy. Patients with HoFH require specialized care and may need LDL apheresis and specific orphan drugs such as lomitapide or evinacumab."
Biomarker • Journal • Review • Atherosclerosis • Cardiovascular • Dyslipidemia • Familial Hypercholesterolemia • Genetic Disorders • Heterozygous Familial Hypercholesterolemia • Homozygous Familial Hypercholesterolemia • Metabolic Disorders • APOB
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Iulia Iatan; Jacques Genest
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