Zileuton protects pancreatic stellate cells from oxidative stress and ferroptosis by modulating the Nrf2 pathway and mitochondrial activity. (PubMed, J Physiol Biochem) - Sep 17, 2026 - "Finally, a drop in the reduction of resazurin by mitochondria and a slowing of the Krebs cycle flow rate were observed, whereas no detectable changes in mitochondrial membrane potential were noted in the presence of zileuton. We conclude that the inhibition of 5-LOX by zileuton places cells in a state of antioxidant readiness coupled with a protected metabolic deceleration."
Journal • Fibrosis • Oncology • Pancreatic Cancer • Solid Tumor • CAT • HMOX1
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Antonio Gonzalez; Cándido Ortiz-Placín; José María Mateos; Juan Iovanna; Matias Estaras; Miguel Fernández-Bermejo; Pablo Solís-Muñoz; Patricia Santofimia-Castaño; Remigio Martínez; Salomé Martínez-Morcillo
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