Comparative adjuvant therapy to reduce vancomycin-associated nephrotoxicity in an animal model. (PubMed, Antimicrob Agents Chemother) - Sep 11, 2026 - "Montelukast only had a marginal effect in vancomycin-treated animals, whereas zileuton significantly delayed nephrotoxicity onset. These findings support further formulation and dose-optimization studies to repurpose zileuton as a renal-protective adjuvant."
Journal • Preclinical • Acute Kidney Injury • Infectious Disease • Nephrology • Renal Disease
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Cole S Hudson; Masayuki Nigo; Nicholas S Teran; Vincent H Tam; Yongqi Xiao
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