Integrated physicochemical profiling, metabolomics and 5-lipoxygenase docking: a comparative analysis of naturally matured acacia honey versus commercial samples. (PubMed, Food Chem) - May 18, 2026 - "Integrated computational approaches and in vitro assays confirmed some MH-enriched metabolites strongly bind 5-LOX with higher affinity than zileuton and inhibit its activity (IC₅₀:72.2 ± 19 to 291.4 ± 53 μmol/L). Phenethyl caffeate, cryptochlorogenic acid, caffeic acid serve as candidate quality markers. These findings support MH's premium quality and in vitro anti-inflammatory potential, facilitating its quality authentication and functional food development."
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Jiakun Zhang; Limei Li; Sijia Tan; Xun Qian; Yongda Chen; Zhenshan Zheng
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