Infection drives excessive platelet inhibition during P2Y12 inhibitor therapy in coronary artery disease (ESC 2026) - May 11, 2026 - Pres time: Aug 30, 2026; 10:15 AM - 11:00 AM; Location: Station 3 (Research Gateway (Hall A1)); "Under arterial shear, baseline thrombus formation was comparable (22% vs. 21%), yet 10 nM cangrelor reduced platelet surface coverage to 9% in infection versus 17% in controls, revealing a heightened sensitivity to P2Y12 inhibition under inflammatory conditions.We recruited a validation cohort comprising patients with established CAD receiving clopidogrel for P2Y12 inhibition. In infection, P2Y12 inhibitor therapy is frequently functionally overdosed. Infection represents a novel and clinically relevant determinant of P2Y12 inhibitor response."
Cardiovascular • Coronary Artery Disease • Thrombosis
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L Weiss1; M Drayss1; D Unsin2; B Just2; K Mott2; H Schulze2
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