Sex-based antibody subclass maturation drives direct enzymatic inhibition in fabry disease patients receiving enzyme replacement therapy. (PubMed, Front Mol Biosci) - Apr 27, 2026 - "Subclass-specific cross-reactivity was assessed for agalsidase alfa, agalsidase beta, and pegunigalsidase alfa. Quantitative subclass-specific ADA and complement profiling reveals sex-specific IgG4 patterns, neutralizing capacity, and ERT-specific immunogenic differences, supporting its utility for personalized therapy in Fabry disease. A novel multiplex LC-MS/MS assay quantifies ADA subclasses and complement in Fabry disease, uncovering distinct IgG4 patterns and ERT-specific profiles that enhance understanding of treatment immunogenicity."
Journal • Fabry Disease • Genetic Disorders
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David Moreno-Martinez; Derralynn Hughes; Francesca Robertson; Hibba Kurdi; Ivan Doykov; James Davison; James Moon; João Augusto; Julien Baruteau; Kevin Mills; Ravi Vijapurapu; Rebecca Kozor; Rick Steeds; Sabrina Nordin; Stefania Rosmini; Tarekegn Geberhiwot; Tomas Baldwin; Uma Ramaswami; Wendy E Heywood
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