Scoparone alleviates cisplatin-induced acute kidney injury by inhibiting 5-lipoxygenase-mediated ferroptosis. (PubMed, Toxicol Appl Pharmacol) - Apr 13, 2026 - "Pharmacological inhibition of ALOX5 with zileuton recapitulated these protective effects, with no additional benefit from co-treatment. Altogether, the findings of this study show that scoparone ameliorates cisplatin-induced AKI by suppressing ALOX5-mediated ferroptosis, positioning ALOX5 as a potential therapeutic target and supporting scoparone as a promising therapeutic candidate for AKI management."
Journal • Acute Kidney Injury • Cardiovascular • Nephrology • Oncology • Renal Disease • ALOX5
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Congcong Dai; Honghao Yu; Jing Mei; Jun Ou; Minhui Xie; Na Huang; Pengpeng Yue; Shuting Huang; Suwan Mu; Suwang Liu; Yong Li; Yuhong Tang
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