Novel Pyrazole-3-Cyano-2-Pyridinone Hybrids as Multitarget Anti-Inflammatory Agents: Synthesis, Computational Modeling, and Biological Evaluation. (PubMed, Drug Des Devel Ther) - Apr 9, 2026 - "Compound 5g most effectively suppressed PGE2 production (IC5 0 = 152.7 pg/mL), while 5m markedly reduced TNF-α levels, comparable to ibuprofen. In LOX assays, compound 5f showed potent inhibition of both 5-LOX (IC5 0 = 0.34 µM) and 15-LOX (IC5 0 = 0.21 µM), outperforming zileuton...In silico pharmacokinetic analysis predicted good oral bioavailability and drug-like properties. The synthesized pyrazole/3-cyano-2-pyridinone hybrids demonstrated promising multi-target anti-inflammatory activity with favorable safety and pharmacokinetic profiles, highlighting their potential as lead candidates for further development."
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Aliaa M Mohassab; Bahgat R M Hussein; Elsayed M Mahmoud; Heba A Hofny; Hossameldin A Aziz; Ibrahim M Salem; Mamdouh F A Mohamed; Omar Alshazly; Stefan Bräse; Tarek S Ibrahim; Zuhier A Awan
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