Proximal Tubular ALOX5 Links Extracellular Matrix Homeostasis and Collagen Remodeling in Renal Fibrosis (KIDNEY WEEK 2026) - Oct 2, 2026 - Abstract #TH-PO0232; Pres time: Oct 22, 2026; 10:00 AM - 12:00 PM; Location: Exhibit Hall A, Convention Center; "Methods Tamoxifen-inducible proximal tubule-specific Alox5 knockout mice were subjected to unilateral ureteral obstruction...HKC-8 cells were stimulated with Alox5-derived metabolites or TGF-β1, while Alox5 activity was inhibited by zileuton or siRNA silencing...Alox5 blockade attenuates fibrosis by suppressing immune activation and inflammatory signaling, restoring ECM homeostasis, and reducing fibrotic collagen accumulation. These findings suggest that proximal tubule-specific Alox5 may serve as a promising upstream therapeutic target for renal fibrosis."
Chronic Kidney Disease • Fibrosis • Immunology • Inflammation • Nephrology • Renal Disease • CCL2 • CXCL12 • ITGAX • TGFB1
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Youngyoon Moon; Hyun Ji Lim; Jeon Hwang-Bo; Tae Hoon Lee; Su Woong Jung; Yang Gyun Kim; Sang ho Lee; Ju young Moon
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