The use of mechanical thrombectomy in patients with STEMI and large thrombus burden: design and rationale of the NATURE trial. (PubMed, Cardiovasc Revasc Med) - Mar 13, 2026 - P=N/A | "Randomization is stratified by site, time from symptom onset (≤ 3 versus >3 h) and intended use of parenteral antiplatelet agents (i.e. glycoprotein IIb/IIIa inhibitors or cangrelor)...The NATURE trial is the first randomized clinical trial aimed at investigating if enVast-assisted mechanical thrombectomy as adjunctive reperfusion strategy is safe and may reduce infarct size in STEMI patients with LTB undergoing primary PCI. TRIAL REGISTRATION: ClinicalTrials.gov number, NCT04969471."
Clinical • Journal • Cardiovascular • Myocardial Infarction • Thrombosis
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Andrea Erriquez; Andrea Milzi; Anna Giulia Pavon; Antonio Colombo; Antonio Landi; Antonio Mangieri; Enrico Frigoli; Eric Lipšic; Florim Cuculi; Gabriele Crimi; Giuseppe Sangiorgi; Jacopo Andrea Oreglia; Jonas D Häner; Juan F Iglesias; Laura Anna Leo; Marco Valgimigli; Martijn Meuwissen; Matthias Bossard; Simone Biscaglia; Valeria Paradies
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