Hippocampal GPR17 is involved in chronic restraint stress-induced depressive-like behaviors by regulating neuroinflammation and glutamatergic activity in mice. (PubMed, Int Immunopharmacol) - Mar 11, 2026 - "Moreover, molecular docking revealed that fluoxetine binds to GPR17. We also found that hippocampal glutamatergic neuronal activity is required for antidepressant-like effects of GPR17 antagonist cangrelor. These results suggest that GPR17 regulates chronic stress-induced depressive-like behaviors and hippocampal synaptic transmission through the TLR4/NF-κB/NLRP3 signaling pathway, establishing it as a promising novel therapeutic target for depression."
Journal • Preclinical • CNS Disorders • Depression • Inflammation • Psychiatry • NLRP3 • TLR4
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Bing Fan; Lei Wu; Rong Hao Mu; Shuai Zhang; Tian Tian Zhi; Xian Wu; Yan Yang; YangXia Wu; Zhi Xie
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