A murine stable thrombosis model enabling therapeutic evaluation of antithrombotic drugs. (PubMed, Blood Vessel Thromb Hemost) - Aug 29, 2026 - "Video microscopy revealed that 0.4 mg/mL cangrelor (P2Y12 inhibitor) or 4 mg/mL GR 144053 trihydrochloride (αIIbβ3 blocker) induced complete disaggregation, whereas 50 IU/mL heparin or 4 mg/mL recombinant tissue plasminogen activator induced destabilization of the thrombus. In contrast, 3.2 mg/mL aspirin, 40 IU/mL unfractionated heparin, or 4 mg/mL hirudin had no effect on a preformed thrombus. Altogether, this model constitutes a valuable platform for assessing therapeutic strategies aimed at stabilizing or dissolving established thrombi."
Journal • Preclinical • Cardiovascular • Hematological Disorders • Thrombosis
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Alexandra Yakusheva; Andréa Thevenot; Andrei Garzon; Anita Eckly; Charlotte E Fauth; Pierre H Mangin
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