Lomitapide reduces viability and clonogenicity in hepatocellular carcinoma cells but enhances xenograft growth: The importance of the tumor microenvironment. (PubMed, J Pharmacol Exp Ther) - Mar 8, 2026 - "SIGNIFICANCE STATEMENT: This study demonstrates that inhibition of microsomal triglyceride transfer protein exerts opposite effects on hepatocellular carcinoma depending on biological context, suppressing tumor cell growth in vitro while promoting tumor expansion in vivo. These findings reveal a decisive role for the tumor microenvironment, particularly stromal cell-derived protumorigenic signals, in shaping therapeutic responses to lipid-modulating drugs."
Biomarker • Journal • Dyslipidemia • Familial Hypercholesterolemia • Genetic Disorders • Hepatocellular Cancer • Homozygous Familial Hypercholesterolemia • Metabolic Disorders • Oncology • Solid Tumor
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Alejo M Capiglioni; Anabela C Ferretti; Ariel D Quiroga; Carla G Comanzo; Florencia Buatti Fagalde; Gerardo B Pisani; Lautaro Hesse; Lucía Oviedo Bustos; María de L Alvarez; María P Ceballos; Marina C Vera; Nicolás F Palma
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