Treatment Effect of Idebenone in Leber Hereditary Optic Neuropathy Using an Alternate Threshold of Clinically Relevant Visual Acuity Change (AAN 2026) - Mar 6, 2026 - Abstract #002; Pres time: Apr 20, 2026; 03:42 PM - 03:54 PM; Location: McCormick Place West | W183c; In-Person; Virtual; P4 | "Conclusions Using the stricter FDA-recommended threshold for clinically relevant VA change to re-assess the LEROS data, idebenone treatment still improved outcomes in many cases. However, treatment effect varied by disease phase and mtDNA mutation."
Clinical • Inherited Retinal Dystrophy • Leber Hereditary Optic Neuropathy • Ocular Inflammation • Ophthalmology • Optic Neuritis • Pain
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Prem Subramanian1; Patrick Yu-Wai-Man2; Valerio Carelli3; Xavier Llòria4; Thomas Klopstock5
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