The Efficacy of Surfactant (curosurf) as Vehicle for Budesonide Delivery to the Lung. (PAS 2026) - Feb 25, 2026 - Abstract #1320.336; Pres time: Apr 24, 2026; 05:30 PM - 08:00 PM; Location: Poster Hall; "Figure 1 showed the radioactivity or budesonide distribution in lung in rat with budesonide alone or with budesonide/surfactant. It is clear that with the use of budesonide/surfactant (curosurf), budesonide can be easily delivered to lung.Figure 2 showed that immediately after intratracheal administration of isotope labeled budesonide/surfactant (curosurf) without prior IMV.Figure 3 showed that after ventilation (VT 8 ml/kg, FiO2 0.6) for 6 hours, with or without LPS, and also 12 hours, budesonide delivery to lung was very low.Conclusion(s): Intratracheal B/S was administered to rat who has been on IMV for 6-12 hours. Budesonide radioactivity was rarely detected in the lung."
Clinical • Surfactant • Respiratory Diseases
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TsuFuh Yeh; Kang Wei Chang; Chih Hsueh Lin; Ming-Chih Lin; Chung-Ming Chen; Mei Hui Wang
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