Discovery of Lomitapide as a Novel Mast Cell Regulatory Agent Through Chemical Library Screening. (PubMed, Eur J Immunol) - Feb 22, 2026 - "Additionally, experiments using a passive cutaneous anaphylaxis (PCA) mouse model demonstrated that lomitapide dampened anaphylactic reactions in vivo. These findings indicate that lomitapide effectively inhibits MC degranulation, which affects allergic responses, suggesting that lomitapide exhibits a novel MC regulatory function and has potential as an anti-allergic therapeutic agent."
Journal • Allergy • Immunology
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Atsushi Furukawa; Ryo Suzuki; Shiori Mamorita; Yuka Nagata
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