Therapeutic targeting of ROCK reverses EMT in lung cancer cells by impeding TAZ in Hippo signalling pathway. (PubMed, Mol Cell Biochem) - Aug 18, 2026 - "At a lower IC50 than the controlled drug Fasudil, Lomitapide also induced increase in cellular ROS, mitochondrial membrane depolarization, G1/S phase cell cycle arrest with increase in apoptotic cell population. Reduction in migration, invasion, colony and sphere forming abilities also supported the annihilation of cancer progression. Overall, the therapeutic potency of Lomitapide was established to target Hippo pathway through disrupting ROCK activity in EMT dynamics."
Journal • Lung Adenocarcinoma • Lung Cancer • Non Small Cell Lung Cancer • Oncology • Solid Tumor • CCND1 • MYC • TAFAZZIN
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Basab Ghosh; Siddhartha Sankar Ghosh
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