Pegunigalsidase alfa improves exercise tolerance and skeletal muscle bioenergetics in a Fabry disease mouse model (SSIEM 2026) - Aug 17, 2026 - Abstract #P-278; Pres time: Aug 26, 2026; 05:30 PM - 06:30 PM; Location: Hall 4&5; "PA treatment enhances exercise endurance and reduces fatigability in FD mice. This effect is likely mediated by improved mitochondrial energetics, rather than rescue of the muscle fiber metabolic switch. Indeed, the glycolytic component and higher power-output of FD skeletal muscle remain unchanged."
Preclinical • Fabry Disease • Genetic Disorders
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Jessica Gambardella 1; Federica Cerasuolo 1; Antonietta Buonaiuto 1; Antonella Fiordelisi 1; Roberta Avvisato 1; Eleonora Riccio 1; Antonio Pisani 1; Daniela Sorriento 1; Guido Iaccarino 1
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