AI-guided CRISPR screening reveals therapeutic targets in psoriasis. (PubMed, Nat Commun) - Jul 7, 2026 - "Topical zileuton, an ALOX5 inhibitor, and cligosiban, an OXTR antagonist, suppress imiquimod-induced psoriasiform dermatitis in mice, mirroring systemic anti-IL17RA antibody efficacy. By linking AI- guided selection to genetic perturbation screening, this study provides an efficient route from candidate gene nomination to biological validation and therapeutic discovery."
Journal • Dermatitis • Dermatology • Immunology • Psoriasis • IL17A
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Abdalla M Abdrabou; Alanur Tutar; Aly A Khan; Amber Lennon; Andrew Kang; Chenlin Zhao; Elizabeth Warren; Jason Perera; Julia M Mayes; Mengqi Jonathan Fan; Mushaine Shih; Pei-Ying Lo; Ryan McClure; Shana O Kelley; Sharif Ahmed; Steven Song
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