Structure-Guided Prioritization and Synthesis of New Ligands for GPR17 Receptor. (PubMed, ACS Omega) - Jun 30, 2026 - "These compounds were synthesized and evaluated using Grating-Coupled Interferometry (GCI), which confirmed nanomolar affinities comparable to the reference antagonist Cangrelor. Functional [35S]-GTPγS binding assays demonstrated that all tested compounds act as GPR17 antagonists, with N 2-n-octyl-, N 2-butyryl- and N 2-undecanoyl-2',3'-O-isopropylideneguanylic acids showing the highest potency. This integrated approach, combining computational modeling, targeted synthesis, and experimental validation, provides a solid foundation for the rational design of selective GPR17 ligands and paves the way for future optimization efforts aimed at therapeutic applications in neurodegenerative disorders and neural tissue repair."
Journal • CNS Disorders
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Davide Bianchi; Enrica Calleri; Francesca Rinaldi; Giovanna Speranza; Irene Balloni; Ivano Eberini; Luca Palazzolo; Marco Rabuffetti; Maria Letizia Trincavelli; Simona Daniele; Stefano Capaldi
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