Imidapril activates CD26/dipeptidyl peptidase IV to alleviate murine choroidal neovascularization by promoting bone marrow cell mobilization and differentiation. (PubMed, Exp Eye Res) - Jun 23, 2026 - "The number of retinal pigment epithelial cells, macrophages and microglia derived from mobilized BMCs significantly increased in CNV areas in response to imidapril treatment. These findings indicate that imidapril influences the CD26/SDF-1 axis to promote BMC mobilization and differentiation in a mouse model of CNV, providing a mechanistic basis for further preclinical and translational investigations."
Journal • Preclinical • CXCL12 • DPP4
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Hong Li; Wei-Qiang Wu; Xiang-Rui Xu; Yan Guo; Yang Lv
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