Precision Editing of Cyclophilin A Generates Cyclosporine and Voclosporin Resistant Cellular Therapies. (PubMed, Blood Immunol Cell Ther) - Oct 24, 2026 - "Edited CMV-specific T cells also demonstrated preserved antigen-specific proliferation and cytokine production in the presence of these drugs. C-terminal editing of Cyclophilin A offers a promising avenue for developing next-generation cell therapies for patients receiving calcineurin inhibitors."
IO biomarker • Journal • Hematological Malignancies • Immunology • Leukemia • Oncology • Transplantation
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Alexandre Albanese; Bruce R Blazar; Elisa J Rojas Palato; Francesca Alvarez Calderon; Franziska Wachter; Gillian Selig; Holly Wobma; Jiayi Dong; Katherine A Michaelis; Kayleigh Omdahl; Leslie S Kean; Lorenzo Cagnin; Marlana Winschel; Peter A Nigrovic; Rene S Bermea; Susan E Prockop; Ulrike Gerdemann; Victor Tkachev; William A Burns; Xianliang Rui
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