Voclosporin Distribution and Clearance from the Kidneys and Cellular Location Following Coadministration with Ketoconazole or Rifampin (KIDNEY WEEK 2025) - Oct 18, 2025 - Abstract #FR-PO0798; Pres time: Nov 7, 2025; 10:00 AM - 12:00 PM; Location: Exhibit Hall, Convention Center; "As VCS demonstrates non-equilibrium disposition following IV and PO administration, drug interaction with KCZ or RIF elevated VCS kidney exposure differentiated from the altered VCS plasma exposure. VCS is rapidly cleared from the kidney and although its retention is modified with CYP inhibition or induction, VCS does not accumulate within the glomeruli or podocytes, with transient flow observed through the cortex, medulla and pelvic regions."
Glomerulonephritis • Renal Disease
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Simon Zhou; Seol Hee Im; Shengnan Duan; Bo Wen; Kathleen O'Rourke Davis; Linda M. Rehaume; Duxin Sun; Buer Song
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