Tacrolimus Versus Voclosporin for Active Lupus Nephritis: A Comparative Meta-analysis of Renal Response (ACR Convergence 2025) - Sep 15, 2025 - Abstract #1546; Pres time: Oct 27, 2025; 10:30 AM - 12:30 PM; Location: Hall F1; In Person; "The approach to active class III and IV LN involves glucocorticoids and mycophenolate mofetil (MMF), with the addition of calcineurin inhibitors (CNIs) based on patient characteristics...Three trials compared TAC with conventional induction regimens (cyclophosphamide or MMF; n = 777)... Based on this meta-analysis, both calcineurin inhibitors improve short-term renal response in active lupus nephritis when added to standard care. Voclosporin shows a larger and more consistent benefit across trials (RR 1.78), whereas tacrolimus exhibits greater between-study variability. Nevertheless, the indirect Bucher comparison does not establish the clear superiority of either drug."
Retrospective data • Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Renal Disease • Systemic Lupus Erythematosus • IL2
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