Tissue resident macrophages derived from induced pluripotent stem cells induce tissue fibrosis in human skin equivalent models of systemic sclerosis (ACR Convergence 2025) - Sep 15, 2025 - Abstract #0974; Pres time: Oct 27, 2025; 10:30 AM - 12:30 PM; Location: Hall F1; In Person; "Treatment with the antifibrotic drug nintedanib, as well as with the CD206-targeting peptide RP-832c (that targets M2 macrophages) effectively reduced collagen deposition in an SSc skin equivalent (containing SSc fibroblasts and SSc TR-Macs). Our study demonstrates a pro-fibrotic role of SSc TR-Macs in SSc skin. Our study demonstrates a pro-fibrotic role of SSc TR-Macs in SSc skin. These Mac subsets are M2-like polarized and promote fibroblast to myofibroblast transition and fibrotic remodelling in an SSc skin equivalent. The SSc skin equivalent model containing TR-Macs recapitulates key fibroblast and Macs subpopulations and their cell-cell communication in SSc skin."
Fibrosis • Immunology • Scleroderma • Systemic Sclerosis • MRC1 • TGFB1
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Xuezhi Hong1; Yanhua Xiao2; shihao zhu3; Yi-Nan Li4; Linlin Huang3; Martin Regensburger5; Franz Marxreiter6; Tim Filla7; Andrea-Hermina Györfi8; James Adjaye9; Jürgen Winkler6; Florian Groeber-Becker10; Jörg Distler11; Alexandru-Emil Matei12
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