Voclosporin promotes neurological function recovery by inhibiting inflammation and maintaining blood-brain barrier integrity following rtPA reperfusion after MCAO in mice. (PubMed, Inflammopharmacology) - Apr 27, 2025 - "By Evans blue extravasation assay and cerebral water content measurement, it was found that voclosporin could improve BBB injury and reduce brain edema caused by rt-PA. The ELISA and immunofluorescence experiments further proved that voclosporin can reduce the expression of IL-1β/TNF-α, increase the expression of IL-10/IL-4, and protect the integrity of the BBB by promoting microglia/macrophage to M2 type polarization, providing new thinking for clinical rtPA combined therapy to alleviate BBB damage."
Journal • Preclinical • Cardiovascular • CNS Disorders • Hematological Disorders • Inflammation • Ischemic stroke • IL10 • IL1B • IL4 • TNFA
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Feng Yan; Shubei Ma; Wei Sun; Yangmin Zheng; Yumin Luo
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