Induced pluripotent stem cell-derived tissue resident macrophage induce profibrotic fibroblast responses in organotypic skin models of systemic sclerosis (EULAR 2025) - Mar 30, 2025 - Abstract #POS0250; L317; Pres time: Jun 13, 2025; 09:54 AM - 10:00 AM; Location: Poster Tour II; "Treatment with the antifibrotic drug nintedanib, as well as with the CD206-targeting peptide RP-832c (that targets M2 macrophages) effectively reduced collagen deposition in an SSc skin equivalent (containing SSc fibroblasts and SSc TR-Macs). Our study demonstrates a pro-fibrotic role of SSc TR-Macs in SSc skin. These Mac subsets are M2-like polarized and promote fibroblast to myofibroblast transition and fibrotic remodelling in an SSc skin equivalent. The SSc skin equivalent model containing TR-Macs recapitulates key fibroblast and Macs subpopulations and their cell-cell communication in SSc skin."
Fibrosis • Immunology • Scleroderma • Systemic Sclerosis • CD163 • MRC1 • TGFB1
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X. Hong 1,2; Y. Xiao 1,2; S. Zhu 1,2; Y. N. Li, L. Huang 1,2; M. Regensburger 5; F. Marxreiter, T. Filla, A. H. Györfi, J. Adjaye, J. Winkler, F. Groeber-Becker 3,4; J. Distler, A. E. Matei
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