PET Imaging of CD206 Macrophages in Bleomycin-Induced Lung Injury Mouse Model. (PubMed, Pharmaceutics) - Feb 26, 2025 - "Background/Objectives: The identification of inflammatory mediators and the involvement of CD206 macrophages in anti-inflammatory responses, along with the synthesis of fibrotic mediators, are crucial for the diagnosis and treatment of Idiopathic Pulmonary Fibrosis (IPF). In contrast, the healthy mice exhibited no detectable CD206 staining, lower PET signals, and reduced radiopharmaceutical accumulation in lung tissues at the same timepoint. These findings suggest that both linear and cyclic [68Ga]Ga-RP832c may function as promising PET imaging agents for CD206 macrophages, and thereby a strategy to non-invasively explore the role of macrophages during fibrogenesis."
Journal • Preclinical • Fibrosis • Idiopathic Pulmonary Fibrosis • Immunology • Inflammation • Pulmonary Disease • Respiratory Diseases • MRC1
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Benjamin M Larimer; Charles Garvin; Clayton Yates; Henry Lopez; Jesse Jaynes; Suzanne E Lapi; Volkan Tekin; Yujun Zhang
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