Childhood-Onset Lupus Nephritis in the Era of Triple Therapy and Steroid Minimization. (PubMed, Children (Basel)) - Jul 29, 2026 - "Contemporary guidance has moved from prolonged high-dose glucocorticoids and cyclophosphamide-dominant treatment toward biopsy-driven, treat-to-target care built around mycophenolic acid analogues, hydroxychloroquine, nephroprotection, rapid steroid tapering, and selected belimumab- or calcineurin-inhibitor-based triple therapy...Pediatric practice must therefore combine adult trial evidence with child-specific caution, explicit adherence strategies, fertility and growth protection, and structured transition planning. The aim should be efficacy without toxicity: not undertreatment, but intelligent, sustainable, developmentally informed treatment."
Journal • Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Pediatrics • Renal Disease • Systemic Lupus Erythematosus
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Anwar Al Omairi; Badria Al Ghaithi; Mohamed S Al Riyami; Naifain Al Kalbani; Naji Al Dhawi; Sulaiman Al Saidi
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