Understanding mechanisms of negative food effect for voclosporin using physiologically based pharmacokinetic modeling. (PubMed, Drug Metab Pharmacokinet) - Oct 22, 2024 - "These results suggest that a possible cause of the negative food effect of voclosporin is the adsorption of voclosporin to food in gastrointestinal tract. These approaches could facilitate understanding of the mechanisms responsible for oral absorption of cyclic peptides."
Journal • PK/PD data • Gastrointestinal Disorder • Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • CYP3A4
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Ayahisa Watanabe; Motohiro Fujiu; Takanori Akazawa
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