Integrative Systems Analyses Reveal Calcineurin Inhibitor-Mediated Control of Human Podocyte Biophysics and Physiology (KIDNEY WEEK 2024) - Sep 23, 2024 - Abstract #SA-PO549; Pres time: Oct 26, 2024; 10:00 AM - 12:00 PM; Location: Exhibit Hall, Convention Center; "Funding: Commercial Support - Aurinia Pharmaceuticals Background: Calcineurin inhibitors (CNIs), such as cyclosporine A (CsA), tacrolimus (TAC), and voclosporin (VCS), have been used to regulate the immune response in a number of conditions, including kidney transplantation, lupus nephritis and other autoimmune disorders. Based on these findings, our study contributes significantly to the understanding of the role of CNIs in podocyte function, independently from other cell biological impacts, and it represents an integrative cellular and molecular atlas to guide the discovery of novel drug-induced modulators of glomerulopathies and evaluate the effect of new CNIs on podocyte biophysical and biomechanical features."
Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Renal Disease
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Jacob M. Wright, MS; Anthony Mendoza, MS; Jonathan C. Haydak, MS; Jenny Wong, PhD; Linda M. Rehaume, PhD; Kirk N. Campbell, MD, FASN; Evren U. Azeloglu, PhD; Maria Paola Santini, MSc, PhD
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