Voclosporin Preserves Mitochondrial Function Compared With Cyclosporine A in Perfused Human Proximal Tubule Microphysiological Systems. (PubMed, bioRxiv) - Jul 18, 2026 - "At matched exposure, VCS preserved mitochondrial function and proteostasis while eliciting a narrower, adaptive ER quality control response. These data support VCS as a nephron-sparing immunosuppressant and 3D MPS as a mechanism-based platform for evaluating renal safety of drugs and nominating early sub-lethal tubular injury biomarkers."
Journal • Transplantation • CDKN1A • KIM1
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Catherine K Yeung; Edward J Kelly; Eric W Hsu; James MacDonald; Jonathan Himmelfarb; Kayenat S Aryeh; Linda M Rehaume; Theo K Bammler; Yik Pui Tsang
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