Selective disposition of voclosporin, cyclosporine, and tacrolimus in renal tissue (UKKW 2024) - Jun 8, 2024 - Abstract #236; 198; Location: CAFE; "Higher drug exposure and >90% renal reabsorption was observed for CSA and TAC, whereas renal handling of VCS suggested significant tubular secretion. The higher rate of secretion and lower overall renal exposure to VCS may be associated with improved safety when compared to the more diffuse distribution and greater renal retention of CSA and TAC."
Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Solid Organ Transplantation
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Dr Simon Zhou1; Dr Krishani Kumari Rajanayake2; Dr Miao He2; Dr Bo Wen2; Dr Ankhbayar Lkhagva2; Dr Ernie Yap1; Dr Duxin Sun2; Dr Jennifer Cross1; Dr Kory Engleke1; Dr Robert Huizinga3; Sadiq Amed4
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