Comparative Effects of Cyclosporine and Voclosporin on Primary Human Proximal Tubular Epithelial Cell (PTEC) Gene Expression (KIDNEY WEEK 2023) - Oct 15, 2023 - Abstract #TH-PO103; Pres time: Nov 2, 2023; 10:00 AM - 12:00 PM; Location: Exhibit Hall, Pennsylvania Convention Center; "Ongoing studies include longer term CNI exposures and effects of CYP3A5 genotype as this enzyme is polymorphic, expressed in the kidney and produces isozyme-specific metabolites of cyclosporine. Our results to date support differential effects of voclosporin versus cyclosporine on PTEC gene expression."
Acute Kidney Injury • Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Renal Disease • Solid Organ Transplantation • Transplantation • CYP3A5 • KIM1
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Theresa Aliwarga1; Linda M. Rehaume2; Catherine K. Yeung1; Jonathan Himmelfarb1; Edward J. Kelly1
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