Does Voclosporin Redefine Lupus Nephritis Treatment? A Tri-Focal View of Efficacy, Safety, and Costs. (PubMed, Curr Med Sci) - Jun 10, 2026 - "Glucocorticoids, hydroxychloroquine, immunosuppressive agents, and calcineurin inhibitors (CNIs) represent the standard therapy...In pivotal phase III trials, the addition of voclosporin to a background of mycophenolate mofetil and low-dose glucocorticoids significantly increased complete renal remission rates and produced a rapid, durable reduction in proteinuria...Voclosporin is also cost effective, as suggested by economic evaluations conducted from multiple national health-system perspectives. The available evidence collectively indicates that voclosporin, through its efficacy, safety, and economic value, enables a more precise, efficient, and comparatively cost-effective treatment paradigm for LN."
Journal • Review • Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • Renal Disease • Systemic Lupus Erythematosus
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Bo-Kun Chen; Meng-Hao Li; Ting-Ting Zhuo; Xin-Hui Zhang; Xiu-Ju Liu; Yun-Fei Tian; Ze-Kun Kang
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