Systemic Sclerosis Macrophages Stimulate Calcinosis in Adipose Derived Mesenchymal Stem Cells via the Activin a Pathway (ACR Convergence 2023) - Sep 24, 2023 - Abstract #2360; Pres time: Nov 14, 2023; 09:00 AM - 11:00 AM; Location: Poster Hall; in person; "Calcinosis occurs in both diffuse and limited SSc subsets and across autoantibody subgroups and was associated with digital ulceration.Elevated plasma levels of Activin A, most notable in anti-Scl70 subgroup, is consistent with systemic upregulation of the Activin A pathway in SSc.Activated macrophages from SSc patients are a potential source of Activin A capable of stimulating MSCs via an osteogenic/calcinosis model.The AUR300 and SB431542 compounds as studied represent potential therapeutic inhibitors of this severe and currently resistant complication of SSc. Figure 1 Role of activin A/ALK5 pathway in SSc macrophages induced calcinosis. (A) Plasma levels of Activin A are raised in diffuse SSc anti-Scl70 (ATA) group."
Fibrosis • Immunology • Metabolic Disorders • Mood Disorders • Scleroderma • Systemic Sclerosis • TGFBR1
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Tamara Searle1; Ujvalla Kalluri1; Sonia Ahmad2; Bahja Ahmed Abdi1; Sandra Lopez1; Shiwen Xu1; Teresa Collins1; Jennifer Cross3; George Martin4; Henry Lopez5; Clayton Yates6; Richard Stratton1
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