TACROLIMUS BUT NOT VOCLOSPORIN INHIBITS KIDNEY TUBULAR CALCIUM AND MAGNESIUM REABSORPTION IN RATS AT CLINICALLY THERAPEUTIC DOSES (ERA-EDTA 2023) - Apr 15, 2023 - Abstract ##4394; Pres time: Jun 16, 2023; 09:15 AM - 09:22 AM; Location: Amber 6; "In contrast to the calcineurin inhibitor tacrolimus, voclosporin does not inhibit the kidney tubular reabsorption of calcium and magnesium and therefore does not cause hypercalciuria or hypomagnesemia. A possible explanation for this difference is that tacrolimus but not voclosporin affects tubular transport in the distal convoluted tubule, which was further supported by the selective inhibition of calbindin-D28K and NCC by tacrolimus. Our data show that tubulotoxicity of tacrolimus is not apparent with voclosporin treatment, at clinically relevant doses."
Preclinical • Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Nephrology • CALB1
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Kuang-Yu Wei1; Martijn H van Heugten1; Hester van Willigenburg1; A. H. Jan Danser1; Linda M. Rehaume2; Jennifer L. Cross2; John J. Viel2; Jeroen de Baaij3; Ewout Hoorn1
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