Kidney adverse events associated with calcineurin inhibitors: a real-world study based on the FAERS database and network pharmacology. (PubMed, Front Med (Lausanne)) - May 4, 2026 - "Revealed significant associations between cyclosporine, tacrolimus, and voclosporin with renal injury, with voclosporin showing stronger correlations (ROR = 5.24, PRR = 4.85, EBGM05 = 4.85, IC025 = 2.28) but lower mortality rates. Network pharmacology analysis suggested that cyclosporine, tacrolimus, and everolimus may exert their toxic effects by acting on core genes. The widespread use of CNIs raises concerns about their renal safety. This study provides new evidence from real-world data indicating differences in renal toxicity risk and mechanisms among calcineurin inhibitors (CNIs), underscoring the importance of pharmacovigilance strategies for patients with autoimmune diseases."
Adverse events • Journal • Real-world evidence • Immunology • Renal Disease
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Jianping Liu; Qian Dai; Xinyu Tan; Yaoyun Liang
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