High-Dose Voclosporin Protects Against Acute Kidney Injury via Regnase-2-Mediated NGAL MRNA Decay. (PubMed, Int J Mol Sci) - Apr 14, 2026 - "This protective effect extended beyond I/R to rhabdomyolysis- and lipopolysaccharide-induced AKI to prevent nephropathy. Our findings demonstrate the potential transformative therapeutic approach of administering high-dose voclosporin to promote the prophylactic effect of Regnase-2 augmentation against AKI in both native and transplanted human kidneys."
Journal • Acute Kidney Injury • Cardiovascular • Glomerulonephritis • Immunology • Inflammatory Arthritis • Lupus • Lupus Nephritis • Metabolic Disorders • Nephrology • Renal Disease • Reperfusion Injury • Transplantation • KIM1
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Chihiro Okinari; Kazuhiro Hasegawa; Makoto Otsuka; Masanori Minato; Masanori Tamaki; Miho Tada; Shinji Miyakami; Shu Wakino; Sumiyo Yamaguchi; Yusuke Sakamaki
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