Myasthenic syndrome in systemic lupus erythematosus successfully treated with plasma exchange: through one of the unexplored faces of neuropsychiatric involvement. (PubMed, Reumatismo) - Apr 10, 2026 - "These neurological features were interpreted as manifestations of NPSLE and were initially treated with azathioprine and then rituximab, the latter discontinued due to an adverse reaction. Several years later, immunosuppressive therapy with mycophenolate mofetil and voclosporin was initiated following a renal flare...The coexistence of SLE and MG is uncommon; distinguishing between an overlap syndrome or lupus-related myasthenic manifestations and choosing the optimal therapeutic strategy remain challenging. In this case, plasma exchange proved to be an effective rescue therapy, highlighting the importance of a multidisciplinary approach and individualized treatment strategies in managing complex NPSLE presentations."
Journal • CNS Disorders • Immunology • Inflammatory Arthritis • Lupus • Myasthenia Gravis • Psychiatry • Systemic Lupus Erythematosus
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Chiara Scirocco; Gian Domenico Sebastiani; Immacolata Prevete; Sara Ferrigno; Valeria Orefice
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