Luteolin protects against cholestasis by suppressing hepatocyte apoptosis through direct PI3K binding and AKT activation. (PubMed, Front Pharmacol) - Oct 27, 2026 - "Additionally, the anti-apoptotic effect of Lut was largely abolished when PI3K was inhibited by LY294002 in vitro...These findings refine the mechanistic understanding of Lut's hepatoprotective action from general antioxidant activity to target-specific anti-apoptotic signaling, and provide a molecular explanation for the traditional use of S. chinensis Benth. for the treatment of damp-heat jaundice."
Journal • Cholestasis • Hepatology • Liver Failure
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Hongyan Liang; Jie Zhang; Peixu Ji; Sipu Wang; Siyao Li; Xiaopei Guo; Xingliang Zhao; Yingchong Xu
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