Hyperoside Derived from Actinidia arguta Bee Pollen Alleviates Zearalenone-Induced Hepatotoxicity and Oxidative Stress in Piglets via the PI3K/AKT Signaling Pathway. (PubMed, J Agric Food Chem) - Oct 26, 2026 - "In vitro validation revealed that HYP phenocopied the AKT activator SC79 in suppressing ZEA-induced hepatocyte apoptosis, an efficacy partially abrogated by the PI3K inhibitor LY294002. Conclusively, HYP ameliorates ZEA-induced hepatotoxicity by activating the PI3K/AKT axis to mitigate oxidative stress and apoptosis, underscoring its translational potential as a functional detoxifying additive for food and feed applications."
Journal • Hepatology • Oncology
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Dongfei You; Guangliang Shi; Nannan Liu; Tianyu Han; Yunfei Jiang
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