Incretin signaling suppresses high glucose-induced β-cell hypoxia through a cAMP/PKA-dependent mechanism. (PubMed, Biochem Biophys Res Commun) - Sep 26, 2026 - "Pharmacological analyses further revealed that the hypoxia-suppressive effect of TZP was mediated predominantly through the cAMP/PKA pathway. These findings identify incretin signaling as an important regulator of β-cell oxygen homeostasis and provide mechanistic insights into the β-cell-protective effects of incretin-based therapies."
Journal • Diabetes • Metabolic Disorders
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Kazuya Yamagata; Masafumi Tsuruta; Paksiree Saranaruk; Yoshifumi Sato
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