FSCN1 Modulates Fatty Acid Metabolism and the Coordinated Activation of AKT/mTOR and p38 MAPK Pathways in Colorectal Cancer Cells. (PubMed, Oncol Res) - Sep 23, 2026 - "Mechanistically, FSCN1 was associated with activation of the protein kinase B/mammalian target of rapamycin (AKT/mTOR) and p38 mitogen-activated protein kinase (p38 MAPK) pathways; pharmacological inhibition with LY294002 or SB203580 phenocopied the lipid-lowering effects of FSCN1 knockdown. Collectively, these findings link FSCN1 to the AKT/mTOR/SREBP1/(FASN/SCD1) lipogenic axis and the p38 MAPK/PPARα/ACOX1 peroxisomal FAO pathway, implicating FSCN1 in lipid metabolic regulation and CRC progression, while suggesting a putative functional regulatory axis and a promising candidate therapeutic target for CRC."
Journal • Colorectal Cancer • Oncology • Solid Tumor • ACOX1 • Fascin • FASN • FSCN1 • mTOR • PPARA • SCD
|
|
Boning Wu; Jialin Zhang; Jieli Song; Peng Huang; Qi Ding; Qiao Liu; Xinya Yu; Xinyu Ju; Yajun Wang; Yupeng Wu; Zhen Li
|