Trimethylamine N-oxide, a Gut Microbiota Metabolite, Promotes Diabetes-Mediated Erectile Dysfunction via a PANoptotic-Like Process Involving Pyroptosis, Apoptosis, and Necroptosis in CCSMCs. (PubMed, Andrology) - Sep 23, 2026 - "Gut microbiota dysbiosis in T1DMED rats was associated with elevated serum TMAO, and TMAO triggered a PANoptotic-like process in CCSMCs via PI3K/Akt activation, thereby contributing to the progression of DMED."
Journal • Diabetes • Erectile Dysfunction • Gastrointestinal Disorder • Metabolic Disorders • Type 1 Diabetes Mellitus • CASP3 • CASP8 • NOS3
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Bo-Wen Tang; Hao Li; Hong-Chen Luan; Jia-Xin Feng; Jin-Ming Di; Jun Chen; Su-Shun Yuan; Wei-He Quan; Ying Chen; Zhan-Sen Huang; Zi-Jun Du
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