Assessment of combined antiviral drug treatment against selected α-, β-, and γ-herpesviruses. (PubMed, Virol J) - Sep 24, 2026 - "The single-drug antiviral treatments identified mean effective concentrations in the micromolar range, for abemaciclib (ABE) and the pharmacophore compound 020 (P-020), as well as submicromolar to nanomolar range, for brincidofovir (BCV) and cyclin-dependent kinase inhibitor of CDK7 (LDC4297). Thus, the study provides new information about antiherpesviral potency and characteristics of a selection of four antiviral prototype inhibitors. Especially, examples of broadness in synergistic combination treatment suggested options to improve antiherpesviral therapy strategies."
Journal • Epstein-Barr Virus Infections • Infectious Disease • CDK7
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Christina Wangen; Debora Obergfäll; Friedrich Hahn; Julia Tillmanns; Kishore Dhotre; Lucio Fortelny; Manfred Marschall
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