Selective inhibition of LY294002 across cloned human cardiac ion channels: implications for atrium-selective therapy in atrial fibrillation. (PubMed, Front Pharmacol) - Sep 25, 2026 - "The inhibitory potency of LY294002 against I Kur is substantially higher than its potency against other major cardiac currents, demonstrating its potential to act as a selective I Kur blocker. Structurally, this preferential inhibition is likely mediated by the compound's favorable occupancy of key gating or pore regions unique to the Kv1.5 channel conformation."
Journal • Atrial Fibrillation • Cardiovascular • NAV1
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Beibei Bie; Bing Zhu; Chao Dong; Hiroshi Matsuura; Huanle Fang; Jiawei Li; Jie Wu; Liang Li; Lie Ma; Mengyuan Chen; Minoru Horie; Ningjuan Han; Rui Niu; Wei Zhao; Yun Fan
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