SYVN1-mediated succinate accumulation exacerbates heart failure. (PubMed, Sci China Life Sci) - Sep 29, 2026 - "Furthermore, we show that the sodium-glucose cotransporter 2 inhibitor empagliflozin binds to NRF1, restores SDHB expression, normalizes succinate levels, and ameliorates cardiac dysfunction in a pressure-overload model. Our findings delineate a novel SYVN1/NRF1/SDHB-succinate axis that drives mitochondrial dysfunction in heart failure, and identify its potential as a therapeutic target for metabolic modulation."
Journal • Cardiovascular • Congestive Heart Failure • Heart Failure • Metabolic Disorders • Targeted Protein Degradation • NRF1 • SDHB • SYVN1
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Erdan Dong; Haiyi Yu; Han Xiao; Hongtu Cui; HuanHuan Cao; Lemin Zheng; Lu Fang; Mingming Zhao; Rui Zhan; Sen Huang; Wei Gao; Wenli Xu; Xiaoyi Liu; Xin Guo; Yanbo Xue; Yawen Deng; Youyi Zhang; Zeshan Zhang
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