Comparative efficacy of AAC and ibuprofen versus lasmiditan, ubrogepant, and rimegepant for the acute treatment of episodic migraine in adults: a systematic review and network meta-analysis. (PubMed, Front Neurol) - Oct 1, 2026 - "Compared with placebo, acetaminophen, aspirin, and caffeine (AAC) combination showed superior 2 h pain relief (RR, 1.76; 95% CI, 1.61-1.94; p-score = 0.96), followed by ibuprofen 400 mg and 200 mg. Larger trials and patient-level analyses are needed to refine efficacy, optimize dosing, and personalize migraine management. https://www.crd.york.ac.uk/PROSPERO/view/CRD420261325571, Identifier CRD420261325571."
Clinical • Journal • Retrospective data • Review • CNS Disorders • Migraine • Pain
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Abhijeet Dhiman; Ashoke Mitra; Billy Franks; Nitu Bansal; Richard Petruschke
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